Activity of a Potent Hepatitis C Virus Polymerase Inhibitor in the Chimpanzee Model

A-837093 is a potent and specific nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase. It possesses nanomolar potencies in both enzymatic and replicon-based cell culture assays. In rats and dogs this compound demonstrated an oral plasma...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Chen, Chih-Ming, He, Yupeng, Lu, Liangjun, Lim, Hock Ben, Tripathi, Rakesh L., Middleton, Tim, Hernandez, Lisa E., Beno, David W. A., Long, Michelle A., Kati, Warren M., Bosse, Todd D., Larson, Daniel P., Wagner, Rolf, Lanford, Robert E., Kohlbrenner, William E., Kempf, Dale J., Pilot-Matias, Tami J., Molla, Akhteruzzaman
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2167986/
https://ncbi.nlm.nih.gov/pubmed/17908950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00723-07
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados