Selection and Characterization of Hepatitis C Virus Replicons Dually Resistant to the Polymerase and Protease Inhibitors HCV-796 and Boceprevir (SCH 503034)

Eitemau Tebyg

• Molecular Mechanism of Hepatitis C Virus Replicon Variants with Reduced Susceptibility to a Benzofuran Inhibitor, HCV-796
  gan: Howe, Anita Y. M., et al.
  Cyhoeddwyd: (2008)
• SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells
  gan: Malcolm, B. A., et al.
  Cyhoeddwyd: (2006)
• Lead Optimization in Discovery Drug Metabolism and Pharmacokinetics/Case study: The Hepatitis C Virus (HCV) Protease Inhibitor SCH 503034
  gan: Cheng, K.-C., et al.
  Cyhoeddwyd: (2007)
• The Combination of Grazoprevir, a Hepatitis C Virus (HCV) NS3/4A Protease Inhibitor, and Elbasvir, an HCV NS5A Inhibitor, Demonstrates a High Genetic Barrier to Resistance in HCV Genotype 1a Replicons
  gan: Lahser, Frederick C., et al.
  Cyhoeddwyd: (2016)
• Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034
  gan: Madison, Vincent, et al.
  Cyhoeddwyd: (2008)