Selection and Characterization of Hepatitis C Virus Replicons Dually Resistant to the Polymerase and Protease Inhibitors HCV-796 and Boceprevir (SCH 503034)

HCV-796 is a nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase, and boceprevir is an inhibitor of the NS3 serine protease. The emergence of replicon variants resistant to the combination of HCV-796 and boceprevir was evaluated. Combining the inhibitors...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Flint, Mike, Mullen, Stanley, Deatly, Anne M., Chen, Wei, Miller, Lynn Z., Ralston, Robert, Broom, Colin, Emini, Emilio A., Howe, Anita Y. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630598/
https://ncbi.nlm.nih.gov/pubmed/18936191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01081-08
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