Molecular Mechanism of Hepatitis C Virus Replicon Variants with Reduced Susceptibility to a Benzofuran Inhibitor, HCV-796

HCV-796 selectively inhibits hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. In hepatoma cells containing a genotype 1b HCV replicon, HCV-796 reduced HCV RNA levels by 3 to 4 log(10) HCV copies/μg total RNA (the concentration of the compound that inhibited 50% of the HCV RNA level was 9 n...

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Detalhes bibliográficos
Main Authors: Howe, Anita Y. M., Cheng, Huiming, Johann, Stephen, Mullen, Stanley, Chunduru, Srinivas K., Young, Dorothy C., Bard, Joel, Chopra, Rajiv, Krishnamurthy, Girija, Mansour, Tarek, O'Connell, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533464/
https://ncbi.nlm.nih.gov/pubmed/18559648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00238-08
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