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GT-1a or GT-1b Subtype-Specific Resistance Profiles for Hepatitis C Virus Inhibitors Telaprevir and HCV-796

In vitro, telaprevir selects subtype-specific resistance pathways for hepatitis C virus GT-1a and GT-1b, as described to have occurred in patients. In GT-1a, the HCV-796 resistance mutation C316Y has low replication capacity (7%) that can be compensated for by the emergence of the mutation L392F or...

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Bibliografiske detaljer
Main Authors: McCown, Matthew F., Rajyaguru, Sonal, Kular, Simran, Cammack, Nick, Nájera, Isabel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681573/
https://ncbi.nlm.nih.gov/pubmed/19273674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01598-08
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