Identification of the NS5B S282T Resistant Variant and Two Novel Amino Acid Substitutions That Affect Replication Capacity in Hepatitis C Virus-Infected Patients Treated with Meric...

Por Tong, Xiao, Li, Lewyn, Haines, Kristin, Najera, Isabel
Publicado em 2014

GT-1a or GT-1b Subtype-Specific Resistance Profiles for Hepatitis C Virus Inhibitors Telaprevir and HCV-796

Por McCown, Matthew F., Rajyaguru, Sonal, Kular, Simran, Cammack, Nick, Nájera, Isabel
Publicado em 2009

Association study between mannose-binding lectin haplotypes and X gene mutation of hepatitis B virus from treatment naïve patients

Por Su, Chenghao, Lin, Yong, Mao, Qianguo, Wu, Daitze, Zhu, Lina, Najera, Isabel, Garcia-Alcalde, Fernando, Niu, Jianjun
Publicado no Aging (Albany NY) (2016)

Similar Prevalence of Low-Abundance Drug-Resistant Variants in Treatment-Naive Patients with Genotype 1a and 1b Hepatitis C Virus Infections as Determined by Ultradeep Pyrosequenci...

Por Margeridon-Thermet, Severine, Le Pogam, Sophie, Li, Lewyn, Liu, Tommy F., Shulman, Nancy, Shafer, Robert W., Najera, Isabel
Publicado em 2014

Mericitabine and Either Boceprevir or Telaprevir in Combination with Peginterferon Alfa-2a plus Ribavirin for Patients with Chronic Hepatitis C Genotype 1 Infection and Prior Null...

Por Wedemeyer, Heiner, Forns, Xavier, Hézode, Christophe, Lee, Samuel S., Scalori, Astrid, Voulgari, Athina, Le Pogam, Sophie, Nájera, Isabel, Thommes, James A.
Publicado no PLoS One (2016)

A Novel Endonuclease Inhibitor Exhibits Broad-Spectrum Anti-Influenza Virus Activity In Vitro

Por Jones, Jeremy C., Marathe, Bindumadhav M., Lerner, Christian, Kreis, Lukas, Gasser, Rodolfo, Pascua, Philippe Noriel Q., Najera, Isabel, Govorkova, Elena A.
Publicado no Antimicrob Agents Chemother (2016)

The Hepatitis C Virus Replicon Presents a Higher Barrier to Resistance to Nucleoside Analogs than to Nonnucleoside Polymerase or Protease Inhibitors

Por McCown, Matthew F., Rajyaguru, Sonal, Le Pogam, Sophie, Ali, Samir, Jiang, Wen-Rong, Kang, Hyunsoon, Symons, Julian, Cammack, Nick, Najera, Isabel
Publicado em 2008

Combinations of Oseltamivir and T-705 Extend the Treatment Window for Highly Pathogenic Influenza A(H5N1) Virus Infection in Mice

Por Marathe, Bindumadhav M., Wong, Sook-San, Vogel, Peter, Garcia-Alcalde, Fernando, Webster, Robert G., Webby, Richard J., Najera, Isabel, Govorkova, Elena A.
Publicado no Sci Rep (2016)

A Novel Immuno-Competitive Capture Mass Spectrometry Strategy for Protein–Protein Interaction Profiling Reveals That LATS Kinases Regulate HCV Replication Through NS5A Phosphorylat...

Por Meistermann, Hélène, Gao, Junjun, Golling, Sabrina, Lamerz, Jens, Le Pogam, Sophie, Tzouros, Manuel, Sankabathula, Sailaja, Gruenbaum, Lore, Nájera, Isabel, Langen, Hanno, Klumpp, Klaus, Augustin, Angélique
Publicado no Mol Cell Proteomics (2014)

Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479

Por Ali, Samir, Leveque, Vincent, Le Pogam, Sophie, Ma, Han, Philipp, Friederike, Inocencio, Nicole, Smith, Mark, Alker, Andre, Kang, Hyunsoon, Najera, Isabel, Klumpp, Klaus, Symons, Julian, Cammack, Nick, Jiang, Wen-Rong
Publicado em 2008

Virologic Escape during Danoprevir (ITMN-191/RG7227) Monotherapy Is Hepatitis C Virus Subtype Dependent and Associated with R155K Substitution

Por Lim, Sharlene R., Qin, Xiaoli, Susser, Simone, Nicholas, John B., Lange, Christian, Herrmann, Eva, Hong, Jin, Arfsten, Ann, Hooi, Lisa, Bradford, Williamson, Nájera, Isabel, Smith, Patrick, Zeuzem, Stefan, Kossen, Karl, Sarrazin, Christophe, Seiwert, Scott D.
Publicado em 2012

Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

Por Le Pogam, Sophie, Kang, Hyunsoon, Harris, Seth F., Leveque, Vincent, Giannetti, Anthony M., Ali, Samir, Jiang, Wen-Rong, Rajyaguru, Sonal, Tavares, Gisele, Oshiro, Connie, Hendricks, Than, Klumpp, Klaus, Symons, Julian, Browner, Michelle F., Cammack, Nick, Nájera, Isabel
Publicado em 2006

Efficacy and Safety of Danoprevir-Ritonavir plus Peginterferon Alfa-2a–Ribavirin in Hepatitis C Virus Genotype 1 Prior Null Responders

Por Gane, Edward J., Rouzier, Régine, Wiercinska-Drapalo, Alicja, Larrey, Dominique G., Morcos, Peter N., Brennan, Barbara J., Le Pogam, Sophie, Nájera, Isabel, Petric, Rosemary, Tran, Jonathan Q., Kulkarni, Rohit, Zhang, Ying, Smith, Patrick, Yetzer, Ellen S., Shulman, Nancy S.
Publicado em 2014

Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus

Por Hang, Julie Qi, Yang, Yanli, Harris, Seth F., Leveque, Vincent, Whittington, Hannah J., Rajyaguru, Sonal, Ao-Ieong, Gloria, McCown, Matthew F., Wong, April, Giannetti, Anthony M., Le Pogam, Sophie, Talamás, Francisco, Cammack, Nick, Nájera, Isabel, Klumpp, Klaus
Publicado em 2009

Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms

Por Zhou, Zheng, Hu, Taishan, Zhou, Xue, Wildum, Steffen, Garcia-Alcalde, Fernando, Xu, Zhiheng, Wu, Daitze, Mao, Yi, Tian, Xiaojun, Zhou, Yuan, Shen, Fang, Zhang, Zhisen, Tang, Guozhi, Najera, Isabel, Yang, Guang, Shen, Hong C., Young, John A. T., Qin, Ning
Publicado no Sci Rep (2017)

Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B

Por Schoenfeld, Ryan C., Bourdet, David L., Brameld, Ken A., Chin, Elbert, de Vicente, Javier, Fung, Amy, Harris, Seth F., Lee, Eun K., Pogam, Sophie Le, Leveque, Vincent, Li, Jim, Lui, Alfred S-T., Najera, Isabel, Rajyaguru, Sonal, Sangi, Michael, Steiner, Sandra, Talamas, Francisco X., Taygerly, Joshua P., Zhao, Junping
Publicado em 2013

Discovery of N-[4-[6-tert-Butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polyme...

Por Talamas, Francisco X., Abbot, Sarah C., Anand, Shalini, Brameld, Ken A., Carter, David S., Chen, Jun, Davis, Dana, de Vicente, Javier, Fung, Amy D., Gong, Leyi, Harris, Seth F., Inbar, Petra, Labadie, Sharada S., Lee, Eun K., Lemoine, Remy, Le Pogam, Sophie, Leveque, Vincent, Li, Jim, McIntosh, Joel, Nájera, Isabel, Park, Jaehyeon, Railkar, Aruna, Rajyaguru, Sonal, Sangi, Michael, Schoenfeld, Ryan C., Staben, Leanna R., Tan, Yunchou, Taygerly, Joshua P., Villaseñor, Armando G., Weller, Paul E.
Publicado em 2013