Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus

The binding affinity of four palm and thumb site representative non-nucleoside inhibitors (NNIs) of HCV polymerase NS5B to wild-type and resistant NS5B polymerase proteins was determined, and the influence of RNA binding on NNI binding affinity was investigated. NNIs with high binding affinity poten...

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Detalhes bibliográficos
Main Authors: Hang, Julie Qi, Yang, Yanli, Harris, Seth F., Leveque, Vincent, Whittington, Hannah J., Rajyaguru, Sonal, Ao-Ieong, Gloria, McCown, Matthew F., Wong, April, Giannetti, Anthony M., Le Pogam, Sophie, Talamás, Francisco, Cammack, Nick, Nájera, Isabel, Klumpp, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
RNA-Mediated Regulation and Noncoding RNAs
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708848/
https://ncbi.nlm.nih.gov/pubmed/19246450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808889200
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