Intracellular Effects of the Hepatitis C Virus Nucleoside Polymerase Inhibitor RO5855 (Mericitabine Parent) and Ribavirin in Combination

Mericitabine (RG7128) is the prodrug of a highly selective cytidine nucleoside analog inhibitor (RO5855) of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. This study evaluated the effects of combining RO5855 and ribavirin on HCV replication in the HCV subgenomic replicon by using two...

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Detalhes bibliográficos
Main Authors: Ma, H., Le Pogam, S., Fletcher, S., Hinojosa-Kirschenbaum, F., Javanbakht, H., Yan, J.-M., Jiang, W.-R., Inocencio, N., Klumpp, K., Nájera, I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993208/
https://ncbi.nlm.nih.gov/pubmed/24550342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02250-13
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