MK-7622: A First-in-Class M(1) Positive Allosteric Modulator Development Candidate

[Image: see text] Identification of ligands that selectively activate the M(1) muscarinic signaling pathway has been sought for decades to treat a range of neurological and cognitive disorders. Herein, we describe the optimization efforts focused on addressing key physicochemical and safety properti...

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書誌詳細
出版年:ACS Med Chem Lett
主要な著者: Beshore, Douglas C., N. Di Marco, Christina, Chang, Ronald K., Greshock, Thomas J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Fuerst, Joy, Hartman, George D., Bilodeau, Mark T., Ray, William J., Kuduk, Scott D.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2018
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047034/
https://ncbi.nlm.nih.gov/pubmed/30034595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00095
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