Drug Design Strategies for GPCR Allosteric Modulators

Por Conn, P. Jeffrey, Kuduk, Scott D., Doller, Darío
Publicado no Annu Rep Med Chem (2012)

A common pharmacophore for cytotoxic natural products that stabilize microtubules

Por Ojima, Iwao, Chakravarty, Subrata, Inoue, Tadashi, Lin, Songnian, He, Lifeng, Horwitz, Susan Band, Kuduk, Scott D., Danishefsky, Samuel J.
Publicado em 1999

Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel

Por Chou, Ting-Chao, Zhang, Xiu-Guo, Harris, Christina R., Kuduk, Scott D., Balog, Aaron, Savin, Kenneth A., Bertino, Joseph R., Danishefsky, Samuel J.
Publicado em 1998

Probing cell-surface architecture through synthesis: An NMR-determined structural motif for tumor-associated mucins

Por Live, David H., Williams, Lawrence J., Kuduk, Scott D., Schwarz, Jacob B., Glunz, Peter W., Chen, Xiao-Tao, Sames, Dalibor, Kumar, R. Ajay, Danishefsky, Samuel J.
Publicado em 1999

Discovery of Naphthyl-Fused 5-Membered Lactams as a New Class of M(1) Positive Allosteric Modulators

Por Yang, Zhi-Qiang, Shu, Youheng, Ma, Lei, Wittmann, Marion, Ray, William J., Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Hartman, George D., Bilodeau, Mark T., Kuduk, Scott D.
Publicado em 2014

Identification of Amides as Carboxylic Acid Surrogates for Quinolizidinone-Based M(1) Positive Allosteric Modulators

Por Kuduk, Scott D., Chang, Ronald K., Greshock, Thomas J., Ray, William J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Hartman, George D., Bilodeau, Mark T.
Publicado em 2012

Quinolizidinone Carboxylic Acids as CNS Penetrant, Selective M(1) Allosteric Muscarinic Receptor Modulators

Por Kuduk, Scott D., Chang, Ronald K., Di Marco, Christina N., Ray, William J., Ma, Lei, Wittmann, Marion, Seager, Matthew A., Koeplinger, Kenneth A., Thompson, Charles D., Hartman, George D., Bilodeau, Mark T.
Publicado em 2010

Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys

Por Tannenbaum, Pamela L., Tye, Spencer J., Stevens, Joanne, Gotter, Anthony L., Fox, Steven V., Savitz, Alan T., Coleman, Paul J., Uslaner, Jason M., Kuduk, Scott D., Hargreaves, Richard, Winrow, Christopher J., Renger, John J.
Publicado no Sleep (2016)

Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs

Por Tannenbaum, Pamela L., Stevens, Joanne, Binns, Jacquelyn, Savitz, Alan T., Garson, Susan L., Fox, Steven V., Coleman, Paul, Kuduk, Scott D., Gotter, Anthony L., Marino, Michael, Tye, Spencer J., Uslaner, Jason M., Winrow, Christopher J., Renger, John J.
Publicado em 2014

Synthesis, Structure−Activity Relationship, and Pharmacological Profile of Analogs of The ASIC-3 Inhibitor A-317567

Por Kuduk, Scott D., Di Marco, Christina N., Bodmer-Narkevitch, Vera, Cook, Sean P., Cato, Matthew J., Jovanovska, Aneta, Urban, Mark O., Leitl, Michael, Sain, Nova, Liang, Annie, Spencer, Robert H., Kane, Stefanie A., Hartman, George D., Bilodeau, Mark T.
Publicado em 2009

Differential sleep-promoting effects of dual orexin receptor antagonists and GABA(A) receptor modulators

Por Gotter, Anthony L, Garson, Susan L, Stevens, Joanne, Munden, Regina L, Fox, Steven V, Tannenbaum, Pamela L, Yao, Lihang, Kuduk, Scott D, McDonald, Terrence, Uslaner, Jason M, Tye, Spencer J, Coleman, Paul J, Winrow, Christopher J, Renger, John J
Publicado no BMC Neurosci (2014)

Quantitative Electroencephalography Within Sleep/Wake States Differentiates GABA(A) Modulators Eszopiclone and Zolpidem From Dual Orexin Receptor Antagonists in Rats

Por Fox, Steven V, Gotter, Anthony L, Tye, Spencer J, Garson, Susan L, Savitz, Alan T, Uslaner, Jason M, Brunner, Joseph I, Tannenbaum, Pamela L, McDonald, Terrence P, Hodgson, Robert, Yao, Lihang, Bowlby, Mark R, Kuduk, Scott D, Coleman, Paul J, Hargreaves, Richard, Winrow, Christopher J, Renger, John J
Publicado em 2013

Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulator...

Por Ramirez, Andres D., Gotter, Anthony L., Fox, Steven V., Tannenbaum, Pamela L., Yao, Lihang, Tye, Spencer J., McDonald, Terrence, Brunner, Joseph, Garson, Susan L., Reiss, Duane R., Kuduk, Scott D., Coleman, Paul J., Uslaner, Jason M., Hodgson, Robert, Browne, Susan E., Renger, John J., Winrow, Christopher J.
Publicado em 2013

The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold

Por Gotter, Anthony L, Winrow, Christopher J, Brunner, Joseph, Garson, Susan L, Fox, Steven V, Binns, Jacquelyn, Harrell, Charles M, Cui, Donghui, Yee, Ka Lai, Stiteler, Mark, Stevens, Joanne, Savitz, Alan, Tannenbaum, Pamela L, Tye, Spencer J, McDonald, Terrence, Yao, Leon, Kuduk, Scott D, Uslaner, Jason, Coleman, Paul J, Renger, John J
Publicado em 2013