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Probing cell-surface architecture through synthesis: An NMR-determined structural motif for tumor-associated mucins

Cell-surface mucin glycoproteins are altered with the onset of oncogenesis. Knowledge of mucin structure could be used in vaccine strategies that target tumor-associated mucin motifs. Thus far, however, mucins have resisted detailed molecular analysis. Reported herein is the solution conformation of...

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Detalhes bibliográficos
Main Authors: Live, David H., Williams, Lawrence J., Kuduk, Scott D., Schwarz, Jacob B., Glunz, Peter W., Chen, Xiao-Tao, Sames, Dalibor, Kumar, R. Ajay, Danishefsky, Samuel J.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22319/
https://ncbi.nlm.nih.gov/pubmed/10097062
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