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Probing cell-surface architecture through synthesis: An NMR-determined structural motif for tumor-associated mucins

Cell-surface mucin glycoproteins are altered with the onset of oncogenesis. Knowledge of mucin structure could be used in vaccine strategies that target tumor-associated mucin motifs. Thus far, however, mucins have resisted detailed molecular analysis. Reported herein is the solution conformation of...

Celý popis

Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Live, David H., Williams, Lawrence J., Kuduk, Scott D., Schwarz, Jacob B., Glunz, Peter W., Chen, Xiao-Tao, Sames, Dalibor, Kumar, R. Ajay, Danishefsky, Samuel J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1999
Témata:
Physical Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22319/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10097062/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.7.3489
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