Shaping suvorexant: application of experimental and theoretical methods for driving synthetic designs

Por McGaughey, Georgia, Bayly, Christopher I., Cox, Christopher D., Schreier, John D., Breslin, Michael J., Bogusky, Michael, Pitzenberger, Steve, Ball, Richard, Coleman, Paul J.
Publicado em 2014

Quantitative Proteomics in Laser Capture Microdissected Sleep Nuclei From Rat Brain

Por Miller, Ronald A., Winrow, Christopher J., Spellman, Daniel S., Song, Qinghua, Reiss, Duane R., Conway, James P., Taylor, Rhonda R., Coleman, Paul J., Hendrickson, Ronald C., Renger, John J.
Publicado em 2014

Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys

Por Tannenbaum, Pamela L., Tye, Spencer J., Stevens, Joanne, Gotter, Anthony L., Fox, Steven V., Savitz, Alan T., Coleman, Paul J., Uslaner, Jason M., Kuduk, Scott D., Hargreaves, Richard, Winrow, Christopher J., Renger, John J.
Publicado no Sleep (2016)

Differential sleep-promoting effects of dual orexin receptor antagonists and GABA(A) receptor modulators

Por Gotter, Anthony L, Garson, Susan L, Stevens, Joanne, Munden, Regina L, Fox, Steven V, Tannenbaum, Pamela L, Yao, Lihang, Kuduk, Scott D, McDonald, Terrence, Uslaner, Jason M, Tye, Spencer J, Coleman, Paul J, Winrow, Christopher J, Renger, John J
Publicado no BMC Neurosci (2014)

Quantitative Electroencephalography Within Sleep/Wake States Differentiates GABA(A) Modulators Eszopiclone and Zolpidem From Dual Orexin Receptor Antagonists in Rats

Por Fox, Steven V, Gotter, Anthony L, Tye, Spencer J, Garson, Susan L, Savitz, Alan T, Uslaner, Jason M, Brunner, Joseph I, Tannenbaum, Pamela L, McDonald, Terrence P, Hodgson, Robert, Yao, Lihang, Bowlby, Mark R, Kuduk, Scott D, Coleman, Paul J, Hargreaves, Richard, Winrow, Christopher J, Renger, John J
Publicado em 2013

Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulator...

Por Ramirez, Andres D., Gotter, Anthony L., Fox, Steven V., Tannenbaum, Pamela L., Yao, Lihang, Tye, Spencer J., McDonald, Terrence, Brunner, Joseph, Garson, Susan L., Reiss, Duane R., Kuduk, Scott D., Coleman, Paul J., Uslaner, Jason M., Hodgson, Robert, Browne, Susan E., Renger, John J., Winrow, Christopher J.
Publicado em 2013

Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man

Por Gotter, Anthony L., Forman, Mark S., Harrell, Charles M., Stevens, Joanne, Svetnik, Vladimir, Yee, Ka Lai, Li, Xiaodong, Roecker, Anthony J., Fox, Steven V., Tannenbaum, Pamela L., Garson, Susan L., Lepeleire, Inge De, Calder, Nicole, Rosen, Laura, Struyk, Arie, Coleman, Paul J., Herring, W. Joseph, Renger, John J., Winrow, Christopher J.
Publicado no Sci Rep (2016)

The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold

Por Gotter, Anthony L, Winrow, Christopher J, Brunner, Joseph, Garson, Susan L, Fox, Steven V, Binns, Jacquelyn, Harrell, Charles M, Cui, Donghui, Yee, Ka Lai, Stiteler, Mark, Stevens, Joanne, Savitz, Alan, Tannenbaum, Pamela L, Tye, Spencer J, McDonald, Terrence, Yao, Leon, Kuduk, Scott D, Uslaner, Jason, Coleman, Paul J, Renger, John J
Publicado em 2013

MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

Por Summa, Vincenzo, Ludmerer, Steven W., McCauley, John A., Fandozzi, Christine, Burlein, Christine, Claudio, Giuliano, Coleman, Paul J., DiMuzio, Jillian M., Ferrara, Marco, Di Filippo, Marcello, Gates, Adam T., Graham, Donald J., Harper, Steven, Hazuda, Daria J., McHale, Carolyn, Monteagudo, Edith, Pucci, Vincenzo, Rowley, Michael, Rudd, Michael T., Soriano, Aileen, Stahlhut, Mark W., Vacca, Joseph P., Olsen, David B., Liverton, Nigel J., Carroll, Steven S.
Publicado em 2012

MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

Por Summa, Vincenzo, Ludmerer, Steven W., McCauley, John A., Fandozzi, Christine, Burlein, Christine, Claudio, Giuliano, Coleman, Paul J., DiMuzio, Jillian M., Ferrara, Marco, Filippo, Marcello Di, Gates, Adam T., Graham, Donald J., Harper, Steven, Hazuda, Daria J., Huang, Qian, McHale, Carolyn, Monteagudo, Edith, Pucci, Vincenzo, Rowley, Michael, Rudd, Michael T., Soriano, Aileen, Stahlhut, Mark W., Vacca, Joseph P., Olsen, David B., Liverton, Nigel J., Carroll, Steven S.
Publicado em 2014

Novel Quinoline-Based P2–P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors

Por Shah, Unmesh, Jayne, Charles, Chackalamannil, Samuel, Velázquez, Francisco, Guo, Zhuyan, Buevich, Alexei, Howe, John A., Chase, Robert, Soriano, Aileen, Agrawal, Sony, Rudd, Michael T., McCauley, John A., Liverton, Nigel J., Romano, Joseph, Bush, Kimberly, Coleman, Paul J., Grisé-Bard, Christiane, Brochu, Marie-Christine, Charron, Sylvie, Aulakh, Virender, Bachand, Benoit, Beaulieu, Patrick, Zaghdane, Helmi, Bhat, Sathesh, Han, Yongxin, Vacca, Joseph P., Davies, Ian W., Weber, Ann E., Venkatraman, Srikanth
Publicado em 2014

Short-Acting T-Type Calcium Channel Antagonists Significantly Modify Sleep Architecture in Rodents

Por Yang, Zhi-Qiang, Schlegel, Kelly-Ann S., Shu, Youheng, Reger, Thomas S., Cube, Rowena, Mattern, Christa, Coleman, Paul J., Small, Jim, Hartman, George D., Ballard, Jeanine, Tang, Cuyue, Kuo, Yuhsin, Prueksaritanont, Thomayant, Nuss, Cindy E., Doran, Scott, Fox, Steve V., Garson, Susan L., Li, Yuxing, Kraus, Richard L., Uebele, Victor N., Taylor, Adekemi B., Zeng, Wei, Fang, Wei, Chavez-Eng, Cynthia, Troyer, Matthew D., Luk, Julie Ann, Laethem, Tine, Cook, William O., Renger, John J., Barrow, James C.
Publicado em 2010

Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

Por Harper, Steven, McCauley, John A., Rudd, Michael T., Ferrara, Marco, DiFilippo, Marcello, Crescenzi, Benedetta, Koch, Uwe, Petrocchi, Alessia, Holloway, M. Katharine, Butcher, John W., Romano, Joseph J., Bush, Kimberly J., Gilbert, Kevin F., McIntyre, Charles J., Nguyen, Kevin T., Nizi, Emanuela, Carroll, Steven S., Ludmerer, Steven W., Burlein, Christine, DiMuzio, Jillian M., Graham, Donald J., McHale, Carolyn M., Stahlhut, Mark W., Olsen, David B., Monteagudo, Edith, Cianetti, Simona, Giuliano, Claudio, Pucci, Vincenzo, Trainor, Nicole, Fandozzi, Christine M., Rowley, Michael, Coleman, Paul J., Vacca, Joseph P., Summa, Vincenzo, Liverton, Nigel J.
Publicado em 2012