Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys

STUDY OBJECTIVES: In addition to enhancing sleep onset and maintenance, a desirable insomnia therapeutic agent would preserve healthy sleep's ability to wake and respond to salient situations while maintaining sleep during irrelevant noise. Dual orexin receptor antagonists (DORAs) promote sleep...

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Detalhes bibliográficos
Publicado no:Sleep
Main Authors: Tannenbaum, Pamela L., Tye, Spencer J., Stevens, Joanne, Gotter, Anthony L., Fox, Steven V., Savitz, Alan T., Coleman, Paul J., Uslaner, Jason M., Kuduk, Scott D., Hargreaves, Richard, Winrow, Christopher J., Renger, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: Associated Professional Sleep Societies, LLC 2016
Assuntos:
Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763356/
https://ncbi.nlm.nih.gov/pubmed/26943466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.5536
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