“It Ain’t Over ’til It’s Over”(a)—The Search for Treatments and Cures for Alzheimer’s Disease

Por Hargreaves, Richard J.
Publicado em 2012

Can Functional Magnetic Resonance Imaging Improve Success Rates in CNS Drug Discovery?

Por Borsook, David, Hargreaves, Richard, Becerra, Lino
Publicado em 2011

Lost but making progress—Where will new analgesic drugs come from?

Por Borsook, David, Hargreaves, Richard, Bountra, Chas, Porreca, Frank
Publicado no Sci Transl Med (2014)

Imaging in CNS drug discovery and development implications for disease and therapy /

Por Borsook, David., Beccera, Lino R., Bullmore, Edward., Hargreaves, Richard J.
Publicado em 2009

The anti-migraine 5-HT(1B/1D) agonist rizatriptan inhibits neurogenic dural vasodilation in anaesthetized guinea-pigs

Por Williamson, David J, Hill, Raymond G, Shepheard, Sara L, Hargreaves, Richard J
Publicado em 2001

Interictal Dysfunction of a Brainstem Descending Modulatory Center in Migraine Patients

Por Moulton, Eric A., Burstein, Rami, Tully, Shannon, Hargreaves, Richard, Becerra, Lino, Borsook, David
Publicado em 2008

Reducing Abuse Liability of GABA(A)/Benzodiazepine Ligands via Selective Partial Agonist Efficacy at α(1) and α(2/3) Subtypes

Por Ator, Nancy A., Atack, John R., Hargreaves, Richard J., Burns, H. Donald, Dawson, Gerard R.
Publicado em 2010

Thalamic sensitization transforms localized pain into widespread allodynia

Por Burstein, Rami, Jakubowski, Moshe, Garcia-Nicas, Esther, Kainz, Vanessa, Bajwa, Zahid, Hargreaves, Richard, Becerra, Lino, Borsook, David
Publicado em 2010

Optical Imaging of Tumor Cells in Hollow Fibers: Evaluation of the Antitumor Activities of Anticancer Drugs and Target Validation

Por Zhang, Guo-Jun, Chen, Tsing-Bau, Bednar, Bohumil, Connolly, Brett M, Hargreaves, Richard, Sur, Cyrille, Williams, David L
Publicado em 2007

Excitatory neurotransmitters in brain regions in interictal migraine patients

Por Prescot, Andrew, Becerra, Lino, Pendse, Gautam, Tully, Shannon, Jensen, Eric, Hargreaves, Richard, Renshaw, Perry, Burstein, Rami, Borsook, David
Publicado em 2009

The plasma–occupancy relationship of the novel GABA(A) receptor benzodiazepine site ligand, α5IA, is similar in rats and primates

Por Atack, John R, Eng, Wai-si, Gibson, Ray E, Ryan, Christine, Francis, Barbara, Sohal, Bindi, Dawson, Gerard R, Hargreaves, Richard J, Burns, H Donald
Publicado em 2009

PET Imaging of Neurokinin-1 Receptors With [(18)F]SPA-RQ in Human Subjects: Assessment of Reference Tissue Models and Their Test–Retest Reproducibility

Por YASUNO, FUMIHIKO, SANABRIA, SANDRA M., BURNS, DONALD, HARGREAVES, RICHARD J., GHOSE, SUBROTO, ICHISE, MASANORI, CHIN, FREDERICK T., MORSE, CHERYL L., PIKE, VICTOR W., INNIS, ROBERT B.
Publicado em 2007

Correlation Between Arterial FDG Uptake and Biomarkers in Peripheral Artery Disease

Por Myers, Kelly S., Rudd, James H. F., Hailman, Eric P., Bolognese, James A., Burke, Joanne, Pinto, Cathy Anne, Klimas, Michael, Hargreaves, Richard, Dansky, Hayes M., Fayad, Zahi A.
Publicado em 2012

Human Biodistribution and Radiation Dosimetry of the Tachykinin NK(1) Antagonist Radioligand [(18)F]SPA-RQ: Comparison of Thin-Slice, Bisected, and 2-Dimensional Planar Image Analy...

Por Sprague, David R., Chin, Frederick T., Liow, Jeih-San, Fujita, Masahiro, Burns, H. Donald, Hargreaves, Richard, Stubbs, James B., Pike, Victor W., Innis, Robert B., Mozley, P. David
Publicado em 2007

Decreased Neurokinin-1 (Substance P) Receptor Binding in Patients with Panic Disorder: Positron Emission Tomographic Study with [(18)F]SPA-RQ

Por Fujimura, Yota, Yasuno, Fumihiko, Farris, Amanda, Liow, Jeih-San, Geraci, Marilla, Drevets, Wayne, Pine, Daniel S., Ghose, Subroto, Lerner, Alicja, Hargreaves, Richard, Burns, H. Donald, Morse, Cheryl, Pike, Victor W., Innis, Robert B.
Publicado em 2009

Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys

Por Tannenbaum, Pamela L., Tye, Spencer J., Stevens, Joanne, Gotter, Anthony L., Fox, Steven V., Savitz, Alan T., Coleman, Paul J., Uslaner, Jason M., Kuduk, Scott D., Hargreaves, Richard, Winrow, Christopher J., Renger, John J.
Publicado no Sleep (2016)

Non-Invasive Bioluminescence Imaging of β-Cell Function in Obese-Hyperglycemic [ob/ob] Mice

Por Patel, Manishkumar, Gleason, Alexa, O'Malley, Stacey, Connolly, Brett, Suresch, Donna, Virostko, John, Phillips, Neil, Lin, Shu-An, Chen, Tsing-Bau, Klimas, Michael, Hargreaves, Richard J., Sur, Cyrille, Williams, David L., Powers, Alvin C., Bednar, Bohumil
Publicado em 2014

Imaging Drugs with and without Clinical Analgesic Efficacy

Por Upadhyay, Jaymin, Anderson, Julie, Schwarz, Adam J, Coimbra, Alexandre, Baumgartner, Richard, Pendse, G, George, Edward, Nutile, Lauren, Wallin, Diana, Bishop, James, Neni, Saujanya, Maier, Gary, Iyengar, Smriti, Evelhoch, Jeffery L, Bleakman, David, Hargreaves, Richard, Becerra, Lino, Borsook, David
Publicado em 2011

Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors

Por Brodbeck, Jens, McGuire, Jim, Liu, Zhaoping, Meyer-Franke, Anke, Balestra, Maureen E., Jeong, Dah-eun, Pleiss, Mike, McComas, Casey, Hess, Fred, Witter, David, Peterson, Scott, Childers, Matthew, Goulet, Mark, Liverton, Nigel, Hargreaves, Richard, Freedman, Stephen, Weisgraber, Karl H., Mahley, Robert W., Huang, Yadong
Publicado em 2011

Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328

Por Harrison, Scott T., Mulhearn, James, Wolkenberg, Scott E., Miller, Patricia J., O’Malley, Stacey S., Zeng, Zhizhen, Williams, David L., Hostetler, Eric D., Sanabria-Bohórquez, Sandra, Gammage, Linda, Fan, Hong, Sur, Cyrille, Culberson, J. Christopher, Hargreaves, Richard J., Cook, Jacquelynn J., Hartman, George D., Barrow, James C.
Publicado em 2011