The plasma–occupancy relationship of the novel GABA(A) receptor benzodiazepine site ligand, α5IA, is similar in rats and primates

BACKGROUND AND PURPOSE: α5IA (3-(5-methylisoxazol-3-yl)-6-[(1-methyl-1,2,3-triazol-4-yl)methyloxy]-1,2,4-triazolo[3,4-a]phthalazine) is a triazolophthalazine with subnanomolar affinity for α1-, α2-, α3- and α5-containing GABA(A) receptors. Here we have evaluated the relationship between plasma α5IA...

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Bibliographische Detailangaben
Hauptverfasser: Atack, John R, Eng, Wai-si, Gibson, Ray E, Ryan, Christine, Francis, Barbara, Sohal, Bindi, Dawson, Gerard R, Hargreaves, Richard J, Burns, H Donald
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2009
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721264/
https://ncbi.nlm.nih.gov/pubmed/19422390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00216.x
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