Reducing Abuse Liability of GABA(A)/Benzodiazepine Ligands via Selective Partial Agonist Efficacy at α(1) and α(2/3) Subtypes

Abuse-liability-related effects of subtype-selective GABA(A) modulators were explored relative to the prototypic benzodiazepine lorazepam. 7-Cyclobutyl-6-(2-methyl-2H-1,2,4-triazol-3-ylmethoxy)-3-phenyl-1,2,4-triazolo[4,3-b]pyridazine (TPA123) has weak partial agonist efficacy at α(1)-, α(2)-, α(3)-...

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Autors principals: Ator, Nancy A., Atack, John R., Hargreaves, Richard J., Burns, H. Donald, Dawson, Gerard R.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2010
Matèries:
Behavioral Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802472/
https://ncbi.nlm.nih.gov/pubmed/19789360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.158303
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