Analgesic potential of PF-06372865, an α2/α3/α5 subtype-selective GABA(A) partial agonist, in humans

BACKGROUND: This study investigated the analgesic effects of two doses (15 and 65 mg) of PF-06372865, a novel α2/α3/α5 gamma-aminobutyric acid A (GABA(A)) subunit selective partial positive allosteric modulator (PAM), compared with placebo and pregabalin (300 mg) as a positive control. METHODS: We p...

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Detalhes bibliográficos
Publicado no:Br J Anaesth
Main Authors: van Amerongen, Guido, Siebenga, Pieter S., Gurrell, Rachel, Dua, Pinky, Whitlock, Mark, Gorman, Donal, Okkerse, Pieter, Hay, Justin L., Butt, Richard P., Groeneveld, Geert Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Pain Mechanisms and Novel Analgesic
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676245/
https://ncbi.nlm.nih.gov/pubmed/30915991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2018.12.006
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