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Analgesic potential of PF-06372865, an α2/α3/α5 subtype-selective GABA(A) partial agonist, in humans
BACKGROUND: This study investigated the analgesic effects of two doses (15 and 65 mg) of PF-06372865, a novel α2/α3/α5 gamma-aminobutyric acid A (GABA(A)) subunit selective partial positive allosteric modulator (PAM), compared with placebo and pregabalin (300 mg) as a positive control. METHODS: We p...
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| Publicado no: | Br J Anaesth |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6676245/ https://ncbi.nlm.nih.gov/pubmed/30915991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2018.12.006 |
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