Lack of Detection of the Analgesic Properties of PF‐05089771, a Selective Na(v)1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects

Sodium channel blockers are used for the treatment of pain, but this is limited by the lack of selectivity for different sodium channel subtypes, which can result in central nervous system and cardiovascular side effects. As such, there is special interest in the Na(v)1.7 subtype, which is expressed...

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Dettagli Bibliografici
Pubblicato in:Clin Transl Sci
Autori principali: Siebenga, Pieter, van Amerongen, Guido, Hay, Justin L., McDonnell, Aoibhinn, Gorman, Donal, Butt, Richard, Groeneveld, Geert Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070789/
https://ncbi.nlm.nih.gov/pubmed/31642607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12712
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