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Demonstration of an anti‐hyperalgesic effect of a novel pan‐Trk inhibitor PF‐06273340 in a battery of human evoked pain models
AIM: Inhibitors of nerve growth factor (NGF) reduce pain in several chronic pain indications. NGF signals through tyrosine kinase receptors of the tropomyosin‐related kinase (Trk) family and the unrelated p75 receptor. PF‐06273340 is a small molecule inhibitor of Trks A, B and C that reduces pain in...
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| Publicado no: | Br J Clin Pharmacol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5777446/ https://ncbi.nlm.nih.gov/pubmed/29178434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13448 |
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