Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABA(A) receptor positive allosteric modulator PF‐06372865

BACKGROUND AND PURPOSE: Benzodiazepines, non‐selective positive allosteric modulators (PAMs) of GABA(A) receptors, have significant side effects that limit their clinical utility. As many of these side effects are mediated by the α1 subunit, there has been a concerted effort to develop α2/3 subtype‐...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Nickolls, Sarah A, Gurrell, Rachel, van Amerongen, Guido, Kammonen, Juha, Cao, Lishuang, Brown, Adam R, Stead, Clara, Mead, Andy, Watson, Christine, Hsu, Cathleen, Owen, Robert M, Pike, Andy, Fish, Rebecca L, Chen, Laigao, Qiu, Ruolun, Morris, Evan D, Feng, Gang, Whitlock, Mark, Gorman, Donal, van Gerven, Joop, Reynolds, David S, Dua, Pinky, Butt, Richard P
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786456/
https://ncbi.nlm.nih.gov/pubmed/29214652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14119
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