Oral Administration of PF-01247324, a Subtype-Selective Nav1.8 Blocker, Reverses Cerebellar Deficits in a Mouse Model of Multiple Sclerosis

por Shields, Shannon D., Butt, Richard P., Dib-Hajj, Sulayman D., Waxman, Stephen G.
Publicado en PLoS One (2015)

Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs

por Siebenga, Pieter S., van Amerongen, Guido, Okkerse, Pieter, Denney, William S., Dua, Pinky, Butt, Richard P., Hay, Justin L., Groeneveld, Geert J.
Publicado en Eur J Pain (2019)

Estimation of binding rate constants using a simultaneous mixed-effects method: application to monoamine transporter reuptake inhibitor reboxetine

por Benson, Neil, Snelder, Nelleke, Ploeger, Bart, Napier, Carolyn, Sale, Harriet, JM Birdsall, Nigel, Butt, Richard P, van der Graaf, Piet H
Publicado 2010

Demonstration of an anti‐hyperalgesic effect of a novel pan‐Trk inhibitor PF‐06273340 in a battery of human evoked pain models

por Loudon, Peter, Siebenga, Pieter, Gorman, Donal, Gore, Katrina, Dua, Pinky, van Amerongen, Guido, Hay, Justin L., Groeneveld, Geert Jan, Butt, Richard P.
Publicado en Br J Clin Pharmacol (2017)

Analgesic potential of PF-06372865, an α2/α3/α5 subtype-selective GABA(A) partial agonist, in humans

por van Amerongen, Guido, Siebenga, Pieter S., Gurrell, Rachel, Dua, Pinky, Whitlock, Mark, Gorman, Donal, Okkerse, Pieter, Hay, Justin L., Butt, Richard P., Groeneveld, Geert Jan
Publicado en Br J Anaesth (2019)

The use of a battery of pain models to detect analgesic properties of compounds: a two‐part four‐way crossover study

por Okkerse, Pieter, van Amerongen, Guido, de Kam, Marieke L., Stevens, Jasper, Butt, Richard P., Gurrell, Rachel, Dahan, Albert, van Gerven, Joop M., Hay, Justin L., Groeneveld, Geert Jan
Publicado en Br J Clin Pharmacol (2017)

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

por McCormack, Ken, Santos, Sonia, Chapman, Mark L., Krafte, Douglas S., Marron, Brian E., West, Christopher W., Krambis, Michael J., Antonio, Brett M., Zellmer, Shannon G., Printzenhoff, David, Padilla, Karen M., Lin, Zhixin, Wagoner, P. Kay, Swain, Nigel A., Stupple, Paul A., de Groot, Marcel, Butt, Richard P., Castle, Neil A.
Publicado 2013

Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABA(A) receptor positive allosteric modulator PF‐06372865

por Nickolls, Sarah A, Gurrell, Rachel, van Amerongen, Guido, Kammonen, Juha, Cao, Lishuang, Brown, Adam R, Stead, Clara, Mead, Andy, Watson, Christine, Hsu, Cathleen, Owen, Robert M, Pike, Andy, Fish, Rebecca L, Chen, Laigao, Qiu, Ruolun, Morris, Evan D, Feng, Gang, Whitlock, Mark, Gorman, Donal, van Gerven, Joop, Reynolds, David S, Dua, Pinky, Butt, Richard P
Publicado en Br J Pharmacol (2018)

A novel selective and orally bioavailable Na(v)1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability

por Payne, Claire Elizabeth, Brown, Adam R, Theile, Jonathon W, Loucif, Alexandre J C, Alexandrou, Aristos J, Fuller, Mathew D, Mahoney, John H, Antonio, Brett M, Gerlach, Aaron C, Printzenhoff, David M, Prime, Rebecca L, Stockbridge, Gillian, Kirkup, Anthony J, Bannon, Anthony W, England, Steve, Chapman, Mark L, Bagal, Sharan, Roeloffs, Rosemarie, Anand, Uma, Anand, Praveen, Bungay, Peter J, Kemp, Mark, Butt, Richard P, Stevens, Edward B
Publicado en Br J Pharmacol (2015)

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

por Alexandrou, Aristos J., Brown, Adam R., Chapman, Mark L., Estacion, Mark, Turner, Jamie, Mis, Malgorzata A., Wilbrey, Anna, Payne, Elizabeth C., Gutteridge, Alex, Cox, Peter J., Doyle, Rachel, Printzenhoff, David, Lin, Zhixin, Marron, Brian E., West, Christopher, Swain, Nigel A., Storer, R. Ian, Stupple, Paul A., Castle, Neil A., Hounshell, James A., Rivara, Mirko, Randall, Andrew, Dib-Hajj, Sulayman D., Krafte, Douglas, Waxman, Stephen G., Patel, Manoj K., Butt, Richard P., Stevens, Edward B.
Publicado en PLoS One (2016)