Adenosine A(1) receptors presynaptically modulate excitatory synaptic input onto subiculum neurons

Por Hargus, Nicholas J., Bertram, Edward H., Patel, Manoj K.
Publicado em 2009

Inhibition of Na(V)1.6 sodium channel currents by a novel series of 1,4-disubstituted-triazole derivatives obtained via copper-catalyzed click chemistry

Por Rivara, Mirko, Patel, Manoj K., Amori, Laura, Zuliani, Valentina
Publicado em 2012

Sodium channel isoform-specific effects of halothane: protein kinase C co-expression and slow inactivation gating

Por Patel, Manoj K, Mistry, Dilaawar, Edward John, J, Paul Mounsey, J
Publicado em 2000

Evidence for a role of Na(v)1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis

Por Hargus, Nicholas J., Nigam, Aradhya, Bertram, Edward H., Patel, Manoj K.
Publicado em 2013

Gabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cord

Por Patel, Manoj K, Gonzalez, M Isabel, Bramwell, Steven, Pinnock, Robert D, Lee, Kevin
Publicado em 2000

Protein kinase C co-expression and the effects of halothane on rat skeletal muscle sodium channels

Por Mounsey, J Paul, Patel, Manoj K, Mistry, Dilaawar, John, J Edward, Moorman, J Randall
Publicado em 1999

Discovery of Diphenyl Amine Based Sodium Channel Blockers, Effective Against hNa(v)1.2

Por Hudgens, Debjani P., Taylor, Catherine, Batts, Timothy W., Patel, Manoj K., Brown, Milton L.
Publicado em 2006

Anticonvulsant Activity of 2,4(1H)-Diarylimidazoles in Mice and Rats Acute Seizure Models

Por Zuliani, Valentina, Fantini, Marco, Nigam, Aradhya, Stables, James P., Patel, Manoj K., Rivara, Mirko
Publicado em 2010

Enhanced Actions of Adenosine in Medial Entorhinal Cortex Layer II Stellate Neurons in Temporal Lobe Epilepsy are Mediated via A(1) Receptor Activation

Por Hargus, Nicholas J., Jennings, Conor, Perez-Reyes, Edward, Bertram, Edward H., Patel, Manoj K.
Publicado em 2011

Comparative Molecular Field Analysis and Synthetic Validation of a Hydroxyamide-Propofol Binding and Functional Block of Neuronal Voltage-Dependent Sodium Channels

Por Brown, Milton L., Eidam, Hilary A., Paige, Mikell, Jones, Paulianda J., Patel, Manoj K.
Publicado em 2008

The SCN8A encephalopathy mutation p.Ile1327Val displays elevated sensitivity to the anticonvulsant phenytoin

Por Barker, Bryan S., Ottolini, Matteo, Wagnon, Jacy L., Hollander, Rachel, Meisler, Miriam H., Patel, Manoj K.
Publicado no Epilepsia (2016)

Ligand-based design and synthesis of novel sodium channel blockers from a combined phenytoin–lidocaine pharmacophore

Por Wang, Yuesheng, Jones, Paulianda J., Batts, Timothy W., Landry, Victoria, Patel, Manoj K., Brown, Milton L.
Publicado em 2008

Distinct domains of the sodium channel β3-subunit modulate channel-gating kinetics and subcellular location

Por Yu, Esther J., Ko, Seong-Hoon, Lenkowski, Paul W., Pance, Alena, Patel, Manoj K., Jackson, Antony P.
Publicado em 2005

Temporal Lobe Epilepsy Induces Intrinsic Alterations in Na Channel Gating in Layer II Medial Entorhinal Cortex Neurons

Por Hargus, Nicholas J., Merrick, Ellen C., Nigam, Aradhya, Kalmar, Christopher L., Baheti, Aparna R., Bertram, Edward H., Patel, Manoj K.
Publicado em 2010

Ca(V)3.2 is the major molecular substrate for redox regulation of T-type Ca(2+) channels in the rat and mouse thalamus

Por Joksovic, Pavle M, Nelson, Michael T, Jevtovic-Todorovic, Vesna, Patel, Manoj K, Perez-Reyes, Edward, Campbell, Kevin P, Chen, Chien-Chang, Todorovic, Slobodan M
Publicado em 2006

Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent

Por Walls, Thomas H., Grindrod, Scott C., Beraud, Dawn, Zhang, Li, Baheti, Aparna R., Dakshanamurthy, Sivanesan, Patel, Manoj K., Brown, Milton L., MacArthur, Linda H.
Publicado em 2012

Modulation of Sodium Channel Inactivation Gating by a Novel Lactam: Implications for Seizure Suppression in Chronic Limbic Epilepsy

Por Jones, Paulianda J., Merrick, Ellen C., Batts, Timothy W., Hargus, Nicholas J., Wang, Yuesheng, Stables, James P., Bertram, Edward H., Brown, Milton L., Patel, Manoj K.
Publicado em 2009

The importance of serine 161 in the sodium channel β3 subunit for modulation of Na(v)1.2 gating

Por Merrick, Ellen C., Kalmar, Christopher L., Snyder, Sandy L., Cusdin, Fiona S., Yu, Ester J., Sando, Julianne J., Isakson, Brant E., Jackson, Antony P., Patel, Manoj K.
Publicado em 2009

Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy

Por Wagnon, Jacy L., Barker, Bryan S., Hounshell, James A., Haaxma, Charlotte A., Shealy, Amy, Moss, Timothy, Parikh, Sumit, Messer, Ricka D., Patel, Manoj K., Meisler, Miriam H.
Publicado no Ann Clin Transl Neurol (2015)

Synthesis and Evaluation of Hermitamides A and B as Human Voltage-Gated Sodium Channel Blockers

Por De Oliveira, Eliseu O., Graf, Kristin M., Patel, Manoj K., Baheti, Aparna, Kong, Hye-Sik, MacArthur, Linda H., Dakshanamurthy, Sivanesan, Wang, Kan, Brown, Milton L., Paige, Mikell
Publicado em 2011