Promoting CRISPRa for Targeted Treatment of Epilepsy

由 Wagnon, Jacy L.
發表在 Epilepsy Curr (2020)

TANGO With SCN1A: Can This Molecular Dance Defeat Dravet Syndrome?

由 Wagnon, Jacy L.
發表在 Epilepsy Curr (2020)

Recurrent and Non-Recurrent Mutations of SCN8A in Epileptic Encephalopathy

由 Wagnon, Jacy L., Meisler, Miriam H.
發表在 Front Neurol (2015)

Functional analysis of three Na(v)1.6 mutations causing Early Infantile Epileptic Encephalopathy

由 Solé, Laura, Wagnon, Jacy L., Tamkun, Michael M.
發表在 Biochim Biophys Acta Mol Basis Dis (2020)

The MAP1B Binding Domain of Na(v)1.6 Is Required for Stable Expression at the Axon Initial Segment

由 Solé, Laura, Wagnon, Jacy L., Akin, Elizabeth J., Meisler, Miriam H., Tamkun, Michael M.
發表在 J Neurosci (2019)

Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice

由 Sun, Wenzhi, Wagnon, Jacy L, Mahaffey, Connie L, Briese, Michael, Ule, Jernej, Frankel, Wayne N
出版 2013

The SCN8A encephalopathy mutation p.Ile1327Val displays elevated sensitivity to the anticonvulsant phenytoin

由 Barker, Bryan S., Ottolini, Matteo, Wagnon, Jacy L., Hollander, Rachel, Meisler, Miriam H., Patel, Manoj K.
發表在 Epilepsia (2016)

Altered gene expression profile in a mouse model of SCN8A encephalopathy

由 Sprissler, Ryan S., Wagnon, Jacy L., Bunton-Stasyshyn, Rosie K., Meisler, Miriam H., Hammer, Michael F.
發表在 Exp Neurol (2016)

Etiology of a genetically complex seizure disorder in Celf4 mutant mice

由 Wagnon, Jacy L., Mahaffey, Connie L., Sun, Wenzhi, Yang, Yan, Chao, Hsiao-Tuan, Frankel, Wayne N.
出版 2011

CELF4 Regulates Translation and Local Abundance of a Vast Set of mRNAs, Including Genes Associated with Regulation of Synaptic Function

由 Wagnon, Jacy L., Briese, Michael, Sun, Wenzhi, Mahaffey, Connie L., Curk, Tomaž, Rot, Gregor, Ule, Jernej, Frankel, Wayne N.
出版 2012

Rapid, efficient and precise allele replacement in the fission yeast Schizosaccharomyces pombe

由 Gao, Jun, Kan, Fengling, Wagnon, Jacy L., Storey, Aaron J., Protacio, Reine M., Davidson, Mari K., Wahls, Wayne P.
出版 2013

Gabra2 is a genetic modifier of Scn8a encephalopathy in the mouse*

由 Yu, Wenxi, Hill, Sophie F., Xenakis, James G., Pardo‐Manuel de Villena, Fernando, Wagnon, Jacy L., Meisler, Miriam H.
發表在 Epilepsia (2020)

A Stress-Activated, p38 Mitogen-Activated Protein Kinase–ATF/CREB Pathway Regulates Posttranscriptional, Sequence-Dependent Decay of Target RNAs

由 Gao, Jun, Wagnon, Jacy L., Protacio, Reine M., Glazko, Galina V., Beggs, Marjorie, Raj, Vinay, Davidson, Mari K., Wahls, Wayne P.
出版 2013

Cardiac arrhythmia in a mouse model of sodium channel SCN8A epileptic encephalopathy

由 Frasier, Chad R., Wagnon, Jacy L., Bao, Yangyang Oliver, McVeigh, Luke G., Lopez-Santiago, Luis F., Meisler, Miriam H., Isom, Lori L.
發表在 Proc Natl Acad Sci U S A (2016)

Loss-of-function variants of SCN8A in intellectual disability without seizures

由 Wagnon, Jacy L., Barker, Bryan S., Ottolini, Matteo, Park, Young, Volkheimer, Alicia, Valdez, Purnima, Swinkels, Marielle E.M., Patel, Manoj K., Meisler, Miriam H.
發表在 Neurol Genet (2017)

Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy

由 Lopez-Santiago, Luis F., Yuan, Yukun, Wagnon, Jacy L., Hull, Jacob M., Frasier, Chad R., O’Malley, Heather A., Meisler, Miriam H., Isom, Lori L.
發表在 Proc Natl Acad Sci U S A (2017)

Convulsive seizures and SUDEP in a mouse model of SCN8A epileptic encephalopathy

由 Wagnon, Jacy L., Korn, Matthew J., Parent, Rachel, Tarpey, Taylor A., Jones, Julie M., Hammer, Michael F., Murphy, Geoffrey G., Parent, Jack M., Meisler, Miriam H.
發表在 Hum Mol Genet (2015)

Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy

由 Wagnon, Jacy L., Barker, Bryan S., Hounshell, James A., Haaxma, Charlotte A., Shealy, Amy, Moss, Timothy, Parikh, Sumit, Messer, Ricka D., Patel, Manoj K., Meisler, Miriam H.
發表在 Ann Clin Transl Neurol (2015)

Partial loss‐of‐function of sodium channel SCN8A in familial isolated myoclonus

由 Wagnon, Jacy L., Mencacci, Niccolò E., Barker, Bryan S., Wengert, Eric R., Bhatia, Kailash P., Balint, Bettina, Carecchio, Miryam, Wood, Nicholas W., Patel, Manoj K., Meisler, Miriam H.
發表在 Hum Mutat (2018)

The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy

由 Baker, Erin M., Thompson, Christopher H., Hawkins, Nicole A., Wagnon, Jacy L., Wengert, Eric R., Patel, Manoj K., George, Alfred L., Meisler, Miriam H., Kearney, Jennifer A.
發表在 Epilepsia (2018)