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The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy

OBJECTIVE: De novo mutations of SCN8A, encoding the voltage-gated sodium channel Nav1.6, have been associated with a severe infant-onset epileptic encephalopathy. Individuals with SCN8A encephalopathy have a mean age of seizure onset of 4–5 months, with multiple seizure types that are often refracto...

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Detalhes bibliográficos
Publicado no:Epilepsia
Main Authors: Baker, Erin M., Thompson, Christopher H., Hawkins, Nicole A., Wagnon, Jacy L., Wengert, Eric R., Patel, Manoj K., George, Alfred L., Meisler, Miriam H., Kearney, Jennifer A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142814/
https://ncbi.nlm.nih.gov/pubmed/29782051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.14196
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