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The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy
OBJECTIVE: De novo mutations of SCN8A, encoding the voltage-gated sodium channel Nav1.6, have been associated with a severe infant-onset epileptic encephalopathy. Individuals with SCN8A encephalopathy have a mean age of seizure onset of 4–5 months, with multiple seizure types that are often refracto...
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Publicado no: | Epilepsia |
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Main Authors: | , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2018
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6142814/ https://ncbi.nlm.nih.gov/pubmed/29782051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.14196 |
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