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Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice

Mice deficient for CELF4, a neuronal RNA-binding protein, have a complex seizure disorder that includes both convulsive and non-convulsive seizures, and is dependent upon Celf4 gene dosage and mouse strain background. It was previously shown that Celf4 is expressed predominantly in excitatory neuron...

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Autores principales: Sun, Wenzhi, Wagnon, Jacy L, Mahaffey, Connie L, Briese, Michael, Ule, Jernej, Frankel, Wayne N
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630783/
https://ncbi.nlm.nih.gov/pubmed/23090952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.240168
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