CELF4 regulates translation and local abundance of a vast set of mRNAs, including genes associated with regulation of synaptic function.

RNA-binding proteins have emerged as causal agents of complex neurological diseases. Mice deficient for neuronal RNA-binding protein CELF4 have a complex neurological disorder with epilepsy as a prominent feature. Human CELF4 has recently been associated with clinical features similar to those seen...

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Opis bibliograficzny

Główni autorzy:	Jacy L Wagnon, Michael Briese, Wenzhi Sun, Connie L Mahaffey, Tomaž Curk, Gregor Rot, Jernej Ule, Wayne N Frankel
Format:	Artigo
Język:	Inglês
Wydane:	Public Library of Science (PLoS) 2012-01-01
Seria:	PLoS Genetics
Dostęp online:	https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003067&type=printable
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