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Gabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cord

In the present study we tested the effects of the antihyperalgesic compound gabapentin on dorsal horn neurones in adult spinal cord. Slices were taken from control and hyperalgesic animals suffering from streptozocin-induced diabetic neuropathy. At concentrations up to 100 μM, bath application faile...

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Detalhes bibliográficos
Main Authors: Patel, Manoj K, Gonzalez, M Isabel, Bramwell, Steven, Pinnock, Robert D, Lee, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572282/
https://ncbi.nlm.nih.gov/pubmed/10952660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703530
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