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Gabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cord

In the present study we tested the effects of the antihyperalgesic compound gabapentin on dorsal horn neurones in adult spinal cord. Slices were taken from control and hyperalgesic animals suffering from streptozocin-induced diabetic neuropathy. At concentrations up to 100 μM, bath application faile...

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Hlavní autoři: Patel, Manoj K, Gonzalez, M Isabel, Bramwell, Steven, Pinnock, Robert D, Lee, Kevin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2000
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572282/
https://ncbi.nlm.nih.gov/pubmed/10952660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703530
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