Synthesis and Evaluation of Hermitamides A and B as Human Voltage-Gated Sodium Channel Blockers

Hermitamides A and B are lipopeptides isolated from a Papau New Guinea collection of the marine cyanobacterium Lyngbya majuscula. We hypothesized that the hermitamides are ligands for the human voltage-gated sodium channel (hNa(V)) based on their structural similarity to the jamaicamides. Herein, we...

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Detalhes bibliográficos
Main Authors: De Oliveira, Eliseu O., Graf, Kristin M., Patel, Manoj K., Baheti, Aparna, Kong, Hye-Sik, MacArthur, Linda H., Dakshanamurthy, Sivanesan, Wang, Kan, Brown, Milton L., Paige, Mikell
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134794/
https://ncbi.nlm.nih.gov/pubmed/21683602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.05.043
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