Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografts

Voltage-gated sodium channels are known to be expressed in neurons and other excitable cells. Recently, voltage-gated sodium channels have been found to be expressed in human prostate cancer cells. α-Hydroxy-α-phenylamides are a new class of small molecules that have demonstrated potent inhibition o...

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Detalhes bibliográficos
Main Authors: Davis, Gary C., Kong, Yali, Paige, Mikell, Li, Zhang, Merrick, Ellen C., Hansen, Todd, Suy, Simeng, Wang, Kan, Dakshanamurthy, Sivanesan, Cordova, Antoinette, McManus, Owen B., Williams, Brande S., Chruszcz, Maksymilian, Minor, Wladek, Patel, Manoj K., Brown, Milton L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111568/
https://ncbi.nlm.nih.gov/pubmed/22364743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.08.061
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