Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografts

Voltage-gated sodium channels are known to be expressed in neurons and other excitable cells. Recently, voltage-gated sodium channels have been found to be expressed in human prostate cancer cells. α-Hydroxy-α-phenylamides are a new class of small molecules that have demonstrated potent inhibition o...

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Main Authors: Davis, Gary C., Kong, Yali, Paige, Mikell, Li, Zhang, Merrick, Ellen C., Hansen, Todd, Suy, Simeng, Wang, Kan, Dakshanamurthy, Sivanesan, Cordova, Antoinette, McManus, Owen B., Williams, Brande S., Chruszcz, Maksymilian, Minor, Wladek, Patel, Manoj K., Brown, Milton L.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111568/
https://ncbi.nlm.nih.gov/pubmed/22364743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.08.061
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