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Comparative Molecular Field Analysis and Synthetic Validation of a Hydroxyamide-Propofol Binding and Functional Block of Neuronal Voltage-Dependent Sodium Channels
Voltage gated sodium channels represent an important therapeutic target for a number of neurological disorders including epilepsy. Unfortunately, medicinal chemistry strategies for discovering new classes of antagonist for trans-membrane ion channels have been limited to mostly broad screening compo...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3569859/ https://ncbi.nlm.nih.gov/pubmed/19747831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.11.069 |
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