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Role of the histidine residue at position 105 in the human α5 containing GABA(A) receptor on the affinity and efficacy of benzodiazepine site ligands

1. A histidine residue in the N-terminal extracellular region of α1,2,3,5 subunits of the human GABA(A) receptor, which is replaced by an arginine in α4 and α6 subunits, is a major determinant for high affinity binding of classical benzodiazepine (BZ)-site ligands. The effect of mutating this histid...

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Hlavní autoři: Kelly, M D, Smith, A, Banks, G, Wingrove, P, Whiting, P W, Atack, J, Seabrook, G R, Maubach, K A
Médium: Artigo
Jazyk:Inglês
Vydáno: 2002
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573121/
https://ncbi.nlm.nih.gov/pubmed/11786501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704459
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