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Different Residues in the GABA(A) Receptor Benzodiazepine Binding Pocket Mediate Benzodiazepine Efficacy and Binding

Benzodiazepines (BZDs) exert their therapeutic actions by binding to the GABA(A) receptor (GABA(A)R) and allosterically modulating GABA-induced chloride currents (I(GABA)). A variety of ligands with divergent structures bind to the BZD site, and the structural mechanisms that couple their binding to...

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Detalhes bibliográficos
Main Authors: Morlock, Elaine V., Czajkowski, Cynthia
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127544/
https://ncbi.nlm.nih.gov/pubmed/21447642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.069542
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