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Identification of Transduction Elements for Benzodiazepine Modulation of the GABA(A) Receptor: Three Residues Are Required for Allosteric Coupling
Modulation of GABA(A) receptors by benzodiazepines (BZDs) is believed to involve two distinct steps: a recognition step in which BZDs bind and a conformational transition step in which the affinity of the receptor for GABA changes. Previously, using γ(2)/α(1) chimeric subunits (χ), we demonstrated t...
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| Published in: | J Neurosci |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Society for Neuroscience
1999
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6782401/ https://ncbi.nlm.nih.gov/pubmed/10575018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-23-10213.1999 |
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