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Curcumol allosterically modulates GABA(A) receptors in a manner distinct from benzodiazepines

Inhibitory A type γ-aminobutyric acid receptors (GABA(A)Rs) play a pivotal role in orchestrating various brain functions and represent an important molecular target in neurological and psychiatric diseases, necessitating the need for the discovery and development of novel modulators. Here, we show t...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Liu, Yan-Mei, Fan, Hui-Ran, Ding, Jing, Huang, Chen, Deng, Shining, Zhu, Tailin, Xu, Tian-Le, Ge, Wei-Hong, Li, Wei-Guang, Li, Fei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5402396/
https://ncbi.nlm.nih.gov/pubmed/28436443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46654
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