Modulating native GABA(A) receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death

PURPOSE: Pediatric brain cancer medulloblastoma (MB) standard-of-care results in numerous comorbidities. MB is comprised of distinct molecular subgroups. Group 3 molecular subgroup patients have the highest relapse rates and after standard-of-care have a 20% survival. Group 3 tumors have high expres...

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Detaylı Bibliyografya
Yayımlandı:J Neurooncol
Asıl Yazarlar: Kallay, Laura, Keskin, Havva, Ross, Alexandra, Rupji, Manali, Moody, Olivia A., Wang, Xin, Li, Guanguan, Ahmed, Taukir, Rashid, Farjana, Stephen, Michael Rajesh, Cottrill, Kirsten A., Nuckols, T. Austin, Xu, Maxwell, Martinson, Deborah E., Tranghese, Frank, Pei, Yanxin, Cook, James M., Kowalski, Jeanne, Taylor, Michael D., Jenkins, Andrew, Pomeranz Krummel, Daniel A., Sengupta, Soma
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer US 2019
Konular:
Laboratory Investigation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478651/
https://ncbi.nlm.nih.gov/pubmed/30725256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-019-03115-0
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