Modulating native GABA(A) receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death

PURPOSE: Pediatric brain cancer medulloblastoma (MB) standard-of-care results in numerous comorbidities. MB is comprised of distinct molecular subgroups. Group 3 molecular subgroup patients have the highest relapse rates and after standard-of-care have a 20% survival. Group 3 tumors have high expres...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Neurooncol
Κύριοι συγγραφείς: Kallay, Laura, Keskin, Havva, Ross, Alexandra, Rupji, Manali, Moody, Olivia A., Wang, Xin, Li, Guanguan, Ahmed, Taukir, Rashid, Farjana, Stephen, Michael Rajesh, Cottrill, Kirsten A., Nuckols, T. Austin, Xu, Maxwell, Martinson, Deborah E., Tranghese, Frank, Pei, Yanxin, Cook, James M., Kowalski, Jeanne, Taylor, Michael D., Jenkins, Andrew, Pomeranz Krummel, Daniel A., Sengupta, Soma
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Springer US 2019
Θέματα:
Laboratory Investigation
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478651/
https://ncbi.nlm.nih.gov/pubmed/30725256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-019-03115-0
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