EXTH-12. RADIATION ENHANCES MELANOMA RESPONSE TO IMMUNOTHERAPY AND SYNERGIZES WITH BENZODIAZEPINES TO PROMOTE ANTI-TUMOR ACTIVITY

Melanoma brain metastases (MBM) occur in ~50% of advanced melanoma patients. It is unclear if systemic therapies synergize with radiotherapy (RT) and what the impact of RT timing has on efficacy. We find that RT followed by ICI (immune checkpoint inhibitors) (RTàICI) improves MBM patient survival co...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Pomeranz Krummel, Daniel, Nasti, Tahseen, Izar, Benjamin, Xu, Maxwell, Lowder, Lindsey, Press, Robert, Kaluzova, Milota, Kallay, Laura, Rupji, Manali, Burnham, Andre, Li, Guanguan, Ahmed, Taukir, Rosen, Havi, Connolly, Erin, Keskin, Havva, Ben Thomas, Midhun, Curran, Walter, Kudchadkar, Ragini, Weinberg, Brent, Olson, Jeffrey, Schniederjan, Matthew, Neil, Stewart, Su, Jing, Lawson, David, Cook, James, Jenkins, Andrew, Kowalski, Jeanne, Khan, Mohammad, Sengupta, Soma
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847525/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.346
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