PDTM-45. POSITIVE MODULATION OF NATIVE GABA(A) RECEPTORS IN MEDULLOBLASTOMA CANCER CELLS WITH BENZODIAZEPINES INDUCES RAPID MITOCHONDRIAL FRAGMENTATION AND TP53-DEPENDENT, CELL CYCLE-INDEPENDENT APOPTOSIS

Medulloblastoma is the most common childhood malignant brain tumor. Children with highest morbidity have tumors that are TP53 wild-type and express high levels of MYC and GABRA5, which codes for the α-5 subunit of the ligand (chloride) gated GABA(A) receptor. Previously, we have established that the...

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Publicado no:Neuro Oncol
Main Authors: Kallay, Laura, Keskin, Havva, Ross, Alexandra, Moody, Olivia, Cottrill, Kirsten, Nuckols, Austin, Li, Guanguan, Ahmed, Taukir, Rashid, Farjana, Stephen, Michael, Xu, Maxwell, Martinson, Deborah, Macdonald, Tobey, Kowalski, Jeanne, Wang, Xin, Taylor, Michael, Cook, James, Jenkins, Andrew, Pomeranz Krummel, Daniel, Sengupta, Soma
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217461/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.884
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