Different Benzodiazepines Bind with Distinct Binding Modes to GABA(A) Receptors

[Image: see text] Benzodiazepines are clinically relevant drugs that bind to GABA(A) neurotransmitter receptors at the α+/γ2– interfaces and thereby enhance GABA-induced chloride ion flux leading to neuronal hyperpolarization. However, the structural basis of benzodiazepine interactions with their h...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:ACS Chem Biol
मुख्य लेखकों: Elgarf, Alshaimaa A., Siebert, David C. B., Steudle, Friederike, Draxler, Angelika, Li, Guanguan, Huang, Shengming, Cook, James M., Ernst, Margot, Scholze, Petra
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2018
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102643/
https://ncbi.nlm.nih.gov/pubmed/29767950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00144
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