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Structure-Guided Computational Methods Predict Multiple Distinct Binding Modes for Pyrazoloquinolinones in GABA(A) Receptors
Pyrazoloquinolinones (PQs) are a versatile class of GABA(A) receptor ligands. It has been demonstrated that high functional selectivity for certain receptor subtypes can be obtained by specific substitution patterns, but so far, no clear SAR rules emerge from the studies. As is the case for many GAB...
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| Pubblicato in: | Front Neurosci |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7844064/ https://ncbi.nlm.nih.gov/pubmed/33519364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.611953 |
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