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NMR Distinction of Single and Multiple-Mode Binding of Small-Molecule Protein Ligands
Identifying and characterizing small-molecule inhibitors of protein-protein interactions is of high interest for drug discovery and for chemical genetics studies of biological pathways. Very often initial hits or first-generation compounds have low-micromolar dissociation constants and cause line br...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2527406/ https://ncbi.nlm.nih.gov/pubmed/16478139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja055971z |
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