Small Molecule Ligands of Methyl-Lysine Binding Proteins

Proteins which bind methylated lysines (“readers” of the histone code) are important components in the epigenetic regulation of gene expression and can also modulate other proteins that contain methyl-lysine such as p53 and Rb. Recognition of methyl-lysine marks by MBT domains leads to compaction of...

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Autori principali: Herold, J. Martin, Wigle, Tim J., Norris, Jacqueline L., Lam, Robert, Korboukh, Victoria K., Gao, Cen, Ingerman, Lindsey A., Kireev, Dmitri B., Senisterra, Guillermo, Vedadi, Masoud, Tripathy, Ashutosh, Brown, Peter J., Arrowsmith, Cheryl H., Jin, Jian, Janzen, William P., Frye, Stephen V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109722/
https://ncbi.nlm.nih.gov/pubmed/21417280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200045v
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