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Small-Molecule Ligands of Methyl-Lysine Binding Proteins: Optimization of Selectivity for L3MBTL3

Lysine methylation is a key epigenetic mark, the dysregulation of which is linked to many diseases. Small molecule antagonism of methyl-lysine (Kme) binding proteins that recognize such epigenetic marks can improve our understanding of these regulatory mechanisms and potentially validate Kme binding...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: James, Lindsey I., Korboukh, Victoria K., Krichevsky, Liubov, Baughman, Brandi M., Herold, J. Martin, Norris, Jacqueline L., Jin, Jian, Kireev, Dmitri B., Janzen, William P., Arrowsmith, Cheryl H., Frye, Stephen V.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3846386/
https://ncbi.nlm.nih.gov/pubmed/24040942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400919p
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