Small-Molecule Ligands of Methyl-Lysine Binding Proteins: Optimization of Selectivity for L3MBTL3

Lysine methylation is a key epigenetic mark, the dysregulation of which is linked to many diseases. Small molecule antagonism of methyl-lysine (Kme) binding proteins that recognize such epigenetic marks can improve our understanding of these regulatory mechanisms and potentially validate Kme binding...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: James, Lindsey I., Korboukh, Victoria K., Krichevsky, Liubov, Baughman, Brandi M., Herold, J. Martin, Norris, Jacqueline L., Jin, Jian, Kireev, Dmitri B., Janzen, William P., Arrowsmith, Cheryl H., Frye, Stephen V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3846386/
https://ncbi.nlm.nih.gov/pubmed/24040942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400919p
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