Novel Therapeutics Targeting Epigenetics: New Molecules, New Methods

بواسطة Frye, Stephen V., Jin, Jian
الحاوية / القاعدة ACS Med Chem Lett (2016)

CHEMICAL GENETIC AND EPIGENETICS: Chemical probes for methyl lysine reader domains

بواسطة James, Lindsey I., Frye, Stephen V.
الحاوية / القاعدة Curr Opin Chem Biol (2016)

Target class drug discovery

بواسطة Barnash, Kimberly D, James, Lindsey I, Frye, Stephen V
الحاوية / القاعدة Nat Chem Biol (2017)

Epigenetics: Tools and Technologies

بواسطة Janzen, William P., Wigle, Tim J., Jin, Jian, Frye, Stephen V.
منشور في 2010

Drug Discovery Toward Antagonists of Methyl-Lysine Binding Proteins

بواسطة Herold, J. Martin, Ingerman, Lindsey A, Gao, Cen, Frye, Stephen V
منشور في 2011

ACADEMIC DRUG DISCOVERY IN THE US: A SURVEY AND ANALYSIS

بواسطة Frye, Stephen V., Crosby, Marina D., Edwards, Teresa P., Juliano, Rudolph L.
الحاوية / القاعدة Nat Rev Drug Discov (2011)

Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay

بواسطة Foley, Caroline A., Potjewyd, Frances, Lamb, Kelsey N., James, Lindsey I., Frye, Stephen V.
الحاوية / القاعدة ACS Chem Biol (2019)

The L3MBTL3 methyl-lysine reader domain functions as a dimer

بواسطة Baughman, Brandi M., Pattenden, Samantha G., Norris, Jacqueline L., James, Lindsey I., Frye, Stephen V.
الحاوية / القاعدة ACS Chem Biol (2015)

Retraction of “The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer”

بواسطة Baughman, Brandi M., Pattenden, Samantha G., Norris, Jacqueline L., James, Lindsey I., Frye, Stephen V.
الحاوية / القاعدة ACS Chem Biol (2017)

Identification of non-peptide Malignant Brain Tumor (MBT) repeat antagonists by Virtual Screening of commercially available compounds

بواسطة Kireev, Dmitri, Wigle, Tim J., Norris-Drouin, Jacqueline, Herold, J. Martin, Janzen, William P., Frye, Stephen V.
منشور في 2010

Accessing Protein Methyltransferase and Demethylase Enzymology Using Microfluidic Capillary Electrophoresis

بواسطة Wigle, Tim J., Provencher, Laurel M., Norris, Jacqueline L., Jin, Jian, Brown, Peter J., Frye, Stephen V., Janzen, William P.
منشور في 2010

AMP Is an Adenosine A(1) Receptor Agonist

بواسطة Rittiner, Joseph E., Korboukh, Ilia, Hull-Ryde, Emily A., Jin, Jian, Janzen, William P., Frye, Stephen V., Zylka, Mark J.
منشور في 2012

Design, synthesis, and protein methyltransferase activity of a unique set of constrained amine containing compounds

بواسطة Zhou, Hao, Che, Xin, Bao, Guochen, Wang, Na, Peng, Li, Barnash, Kimberly D., Frye, Stephen V., James, Lindsey I., Bai, Xu
الحاوية / القاعدة Bioorg Med Chem Lett (2016)

A General TR-FRET Assay Platform for High-Throughput Screening and Characterizing Inhibitors of Methyl-Lysine Reader Proteins

بواسطة Rectenwald, Justin M., Hardy, P. Brian, Norris-Drouin, Jacqueline L., Cholensky, Stephanie, James, Lindsey I., Frye, Stephen V., Pearce, Kenneth H.
الحاوية / القاعدة SLAS Discov (2019)

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

بواسطة Baughman, Brandi M., Wang, Huanchen, An, Yi, Kireev, Dmitri, Stashko, Michael A., Jessen, Henning J., Pearce, Kenneth H., Frye, Stephen V., Shears, Stephen B.
الحاوية / القاعدة PLoS One (2016)

Retraction: A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

بواسطة Baughman, Brandi M., Wang, Huanchen, An, Yi, Kireev, Dmitri, Stashko, Michael A., Jessen, Henning J., Pearce, Kenneth H., Frye, Stephen V., Shears, Stephen B.
الحاوية / القاعدة PLoS One (2017)

Structure-Functional Selectivity Relationship Studies of β-arrestin-biased Dopamine D(2) Receptor Agonists

بواسطة Chen, Xin, Sassano, Maria F., Zheng, Lianyou, Setola, Vincent, Chen, Meng, Bai, Xu, Frye, Stephen V., Wetsel, William C., Roth, Bryan L., Jin, Jian
منشور في 2012

Chromodomain Ligand Optimization via Target-Class Directed Combinatorial Repurposing

بواسطة Barnash, Kimberly D., Lamb, Kelsey N., Stuckey, Jacob I., Norris, Jacqueline L., Cholensky, Stephanie H., Kireev, Dmitri B., Frye, Stephen V., James, Lindsey I.
الحاوية / القاعدة ACS Chem Biol (2016)

Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1)

بواسطة Engelberg, Isabelle A., Liu, Jiuyang, Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Ottavi, Samantha A., Frye, Stephen V., Kutateladze, Tatiana G., James, Lindsey I.
الحاوية / القاعدة J Med Chem (2021)

Small molecule inhibition of MERTK is efficacious in non-small cell lung cancer models independent of driver oncogene status

بواسطة Cummings, Christopher T., Zhang, Weihe, Davies, Kurtis D., Kirkpatrick, Gregory D., Zhang, Dehui, DeRyckere, Deborah, Wang, Xiaodong, Frye, Stephen V., Earp, H. Shelton, Graham, Douglas K.
الحاوية / القاعدة Mol Cancer Ther (2015)