Chromodomain Ligand Optimization via Target-Class Directed Combinatorial Repurposing

Efforts to develop strategies for small molecule chemical probe discovery against the readers of the methyl-lysine (Kme) post-translational modification have been met with limited success. Targeted disruption of these protein-protein interactions via peptidomimetic inhibitor optimization is a promis...

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Publicat a:ACS Chem Biol
Autors principals: Barnash, Kimberly D., Lamb, Kelsey N., Stuckey, Jacob I., Norris, Jacqueline L., Cholensky, Stephanie H., Kireev, Dmitri B., Frye, Stephen V., James, Lindsey I.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026585/
https://ncbi.nlm.nih.gov/pubmed/27356154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00415
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