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Discovery and Characterization of a Cellularly Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7
Polycomb-directed repression of gene expression is frequently misregulated in human diseases. A quantitative and target-specific cellular assay was utilized to discover the first potent positive allosteric modulator (PAM) peptidomimetic, UNC4976, of nucleic acid binding by CBX7, a chromodomain methy...
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| Publié dans: | Cell Chem Biol |
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6800648/ https://ncbi.nlm.nih.gov/pubmed/31422906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.07.013 |
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