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Discovery and Characterization of a Cellularly Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7

Polycomb-directed repression of gene expression is frequently misregulated in human diseases. A quantitative and target-specific cellular assay was utilized to discover the first potent positive allosteric modulator (PAM) peptidomimetic, UNC4976, of nucleic acid binding by CBX7, a chromodomain methy...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Lamb, Kelsey N., Bsteh, Daniel, Dishman, Sarah N., Moussa, Hagar F., Fan, Huitao, Stuckey, Jacob I., Norris, Jacqueline L., Cholensky, Stephanie H., Li, Dongxu, Wang, Jingkui, Sagum, Cari, Stanton, Benjamin Z., Bedford, Mark T., Pearce, Kenneth H., Kenakin, Terry P., Kireev, Dmitri B., Wang, Gang Greg, James, Lindsey I., Bell, Oliver, Frye, Stephen V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800648/
https://ncbi.nlm.nih.gov/pubmed/31422906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.07.013
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