Discovery and Characterization of a Cellularly Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7

Polycomb-directed repression of gene expression is frequently misregulated in human diseases. A quantitative and target-specific cellular assay was utilized to discover the first potent positive allosteric modulator (PAM) peptidomimetic, UNC4976, of nucleic acid binding by CBX7, a chromodomain methy...

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Publicat a:Cell Chem Biol
Autors principals: Lamb, Kelsey N., Bsteh, Daniel, Dishman, Sarah N., Moussa, Hagar F., Fan, Huitao, Stuckey, Jacob I., Norris, Jacqueline L., Cholensky, Stephanie H., Li, Dongxu, Wang, Jingkui, Sagum, Cari, Stanton, Benjamin Z., Bedford, Mark T., Pearce, Kenneth H., Kenakin, Terry P., Kireev, Dmitri B., Wang, Gang Greg, James, Lindsey I., Bell, Oliver, Frye, Stephen V.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800648/
https://ncbi.nlm.nih.gov/pubmed/31422906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.07.013
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