Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2

The function of EED within Polycomb repressive complex 2 (PRC2) is mediated by a complex network of protein-protein interactions. Allosteric activation of PRC2 by binding of methylated proteins to embryonic ectoderm development (EED) aromatic cage is essential for full catalytic activity, but detail...

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Publié dans:ACS Comb Sci
Auteurs principaux: Barnash, Kimberly D., The, Juliana, Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Worley, Beau M., Li, Fengling, Stuckey, Jacob I., Brown, Peter J., Vedadi, Masoud, Arrowsmith, Cheryl H., Frye, Stephen V., James, Lindsey I.
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376495/
https://ncbi.nlm.nih.gov/pubmed/28165227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.6b00174
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