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Degradation of Polycomb Repressive Complex 2 with an EED-targeted Bivalent Chemical Degrader

Protein degradation via the use of bivalent chemical degraders provides an alternative strategy to block protein function and assess the biological roles of putative drug targets. This approach capitalizes on the advantages of small molecule inhibitors while moving beyond the restrictions of traditi...

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Bibliografski detalji
Izdano u:Cell Chem Biol
Glavni autori: Potjewyd, Frances, Turner, Anne-Marie W., Beri, Joshua, Rectenwald, Justin M, Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Margolis, David M., Pearce, Kenneth H., Herring, Laura E., James, Lindsey I.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7004250/
https://ncbi.nlm.nih.gov/pubmed/31831267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.11.006
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