Degradation of Polycomb Repressive Complex 2 with an EED-targeted Bivalent Chemical Degrader

Protein degradation via the use of bivalent chemical degraders provides an alternative strategy to block protein function and assess the biological roles of putative drug targets. This approach capitalizes on the advantages of small molecule inhibitors while moving beyond the restrictions of traditi...

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Détails bibliographiques
Publié dans:Cell Chem Biol
Auteurs principaux: Potjewyd, Frances, Turner, Anne-Marie W., Beri, Joshua, Rectenwald, Justin M, Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Margolis, David M., Pearce, Kenneth H., Herring, Laura E., James, Lindsey I.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7004250/
https://ncbi.nlm.nih.gov/pubmed/31831267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.11.006
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