Degradation of Polycomb Repressive Complex 2 with an EED-targeted Bivalent Chemical Degrader

Protein degradation via the use of bivalent chemical degraders provides an alternative strategy to block protein function and assess the biological roles of putative drug targets. This approach capitalizes on the advantages of small molecule inhibitors while moving beyond the restrictions of traditi...

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Bibliographic Details
Published in:Cell Chem Biol
Main Authors: Potjewyd, Frances, Turner, Anne-Marie W., Beri, Joshua, Rectenwald, Justin M, Norris-Drouin, Jacqueline L., Cholensky, Stephanie H., Margolis, David M., Pearce, Kenneth H., Herring, Laura E., James, Lindsey I.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7004250/
https://ncbi.nlm.nih.gov/pubmed/31831267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.11.006
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